Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members.

@article{Bowman1998RegulationOC,
  title={Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members.},
  author={Edward P. Bowman and James J Campbell and Kirk M. Druey and A Scheschonka and John H Kehrl and Eugene C. Butcher},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 43},
  pages={
          28040-8
        }
}
Serpentine Galphai-linked receptors support rapid adhesion and directed migration of leukocytes and other cell types. The intracellular mechanisms mediating and regulating chemoattractant-directed adhesion and locomotion are only now beginning to be explored. RGS (for regulator of G-protein signaling) proteins are a recently described family that regulate Galphai-stimulated pathways by acting as GTPase-activating proteins. Little is known about the GTPase activity of the Galphai proteins… CONTINUE READING
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