Regulation of chemosensitivity and migration by clusterin in non-small cell lung cancer cells

@article{Cheng2011RegulationOC,
  title={Regulation of chemosensitivity and migration by clusterin in non-small cell lung cancer cells},
  author={C P Cheng and S H Cherng and Wen-jun Wu and Tsung-Ying Yang and Xin-Yi Huang and Fu-Tien Liao and Ming-Fang Wu and G F Sheu},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2011},
  volume={69},
  pages={145-154}
}
In terms of drug resistance, cancer cells usually benefit from high clusterin (CLU) expression on chemotherapy. In contrast, CLU expression has been found to be a favorable prognostic factor in lung cancer patients. The aims of this study are to determine the association between CLU expression and chemotherapeutic sensitivity and the potential role of CLU in migration in human non-small-cell lung cancer (NSCLC) cell lines. The levels of clusterin in NSCLC cell lines were altered by short… CONTINUE READING
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