Regulation of chemokine receptor expression in human microglia and astrocytes

@article{Flynn2003RegulationOC,
  title={Regulation of chemokine receptor expression in human microglia and astrocytes},
  author={G. Flynn and Seema Maru and J. Loughlin and I. Romero and D. Male},
  journal={Journal of Neuroimmunology},
  year={2003},
  volume={136},
  pages={84-93}
}
It has been proposed that the positioning of mobile cells within a tissue is determined by their overall profile of chemokine receptors. This study examines the profiles of chemokine receptors expressed on resting and activated adult human microglial cells, astrocytes and a microglial cell line, CHME3. Microglia express highest levels of CXCR1, CXCR3 and CCR3. Astrocytes also have moderate levels of CXCR1 and CXCR3, and some CCR3, while both cell types also expressed CCR4, CCR5, CCR6, CXCR2… Expand
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