Regulation of chemokine gene expression in human peripheral blood neutrophils phagocytosing microbial pathogens.

@article{Hachicha1998RegulationOC,
  title={Regulation of chemokine gene expression in human peripheral blood neutrophils phagocytosing microbial pathogens.},
  author={Mohamed Hachicha and Palaniswami Rathanaswami and Paul H. Naccache and Shaun R McColl},
  journal={Journal of immunology},
  year={1998},
  volume={160 1},
  pages={449-54}
}
Production of chemokines (chemotactic cytokines) by neutrophils is likely to be important in the regulation of inflammation and the control of infection. In this study we show that exposure of human neutrophils to various microbial pathogens leads to the production of both macrophage inflammatory protein 1alpha (MIP-1alpha) and IL-8. The bacterial microbes, Salmonella typhimurium and Pseudomonas aeruginosa, and Staphylococcus aureus all strongly induced both IL-8 and MIP-1alpha secretion… CONTINUE READING

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