Regulation of ceramide synthase by casein kinase 2-dependent phosphorylation in Saccharomyces cerevisiae.

@article{Fresques2015RegulationOC,
  title={Regulation of ceramide synthase by casein kinase 2-dependent phosphorylation in Saccharomyces cerevisiae.},
  author={Tara Fresques and Brad J. Niles and Sofia Aronova and Huzefa Mogri and Taha Rakhshandehroo and Ted Powers},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 3},
  pages={1395-403}
}
Complex sphingolipids are important components of eukaryotic cell membranes and, together with their biosynthetic precursors, including sphingoid long chain bases and ceramides, have important signaling functions crucial for cell growth and survival. Ceramides are produced at the endoplasmic reticulum (ER) membrane by a multicomponent enzyme complex termed ceramide synthase (CerS). In budding yeast, this complex is composed of two catalytic subunits, Lac1 and Lag1, as well as an essential… CONTINUE READING
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