Regulation of central 5-HT2A receptors: a review of in vivo studies

  title={Regulation of central 5-HT2A
 receptors: a review of in vivo studies},
  author={Arlene Stark Eison and U L Mullins},
  journal={Behavioural Brain Research},

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Do classical hallucinogens act as 5-HT2 agonists or antagonists?

  • R. Glennon
  • Biology
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
  • 1990
A review of the existing literature suggests that where a 5-HT2 mechanism has been implicated (such as in phosphoinositide turnover, contraction of certain smooth muscle, rat-paw edema, head-twitch behavior, discriminative stimulus effects, hyperthermia, platelet aggregation, and in various other effects), the classical hallucinogens are most likely acting via an agonist, or at least via a partial agonists mechanism.