Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes.

@article{Klebes2005RegulationOC,
  title={Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes.},
  author={Ansgar Klebes and Anne Sustar and Katherina J Kechris and Hao Nan Li and Gerold Schubiger and Thomas B Kornberg},
  journal={Development},
  year={2005},
  volume={132 16},
  pages={3753-65}
}
Drosophila imaginal disc cells can switch fates by transdetermining from one determined state to another. We analyzed the expression profiles of cells induced by ectopic Wingless expression to transdetermine from leg to wing by dissecting transdetermined cells and hybridizing probes generated by linear RNA amplification to DNA microarrays. Changes in expression levels implicated a number of genes: lamina ancestor, CG12534 (a gene orthologous to mouse augmenter of liver regeneration), Notch… CONTINUE READING
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