Regulation of cell wallβ-glucan assembly:PTC1 Negatively affectsPBS2 Action in a pathway that includes modulation ofEXG1 transcription

@article{Jiang1995RegulationOC,
  title={Regulation of cell wallβ-glucan assembly:PTC1 Negatively affectsPBS2 Action in a pathway that includes modulation ofEXG1 transcription},
  author={Bo Jiang and Arthur F. J. Ram and Jane Sheraton and Frans Klis and Howard A Bussey},
  journal={Molecular and General Genetics MGG},
  year={1995},
  volume={248},
  pages={260-269}
}
Analysis of genes involved in yeast cell wallβ-glucan assembly has led to the isolation ofEXG1,PBS2 andPTC1.EXG1 andPBS2 were isolated as genes that, when expressed from multicopy plasmids, led to a dominant killer toxin-resistant phenotype. ThePTC1 gene was cloned by functional complementation of the calcofluor white-hypersensitive mutantcwh47-1.PTC1/CWH47 is the structural gene for a type 2C serine/threonine phosphatase,EXG1 codes for an exo-β-glucanase, andPBS2 encodes a MAP kinase kinase in… CONTINUE READING

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