Regulation of cell survival by secreted proneurotrophins.

  title={Regulation of cell survival by secreted proneurotrophins.},
  author={Roberta Anne Lee and Pouneh Kermani and Kenneth K Teng and Barbara L. Hempstead},
  volume={294 5548},
Neurotrophins are growth factors that promote cell survival, differentiation, and cell death. They are synthesized as proforms that can be cleaved intracellularly to release mature, secreted ligands. Although proneurotrophins have been considered inactive precursors, we show here that the proforms of nerve growth factor (NGF) and the proforms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease plasmin and by selective matrix… CONTINUE READING
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