Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells.

@article{Iida2000RegulationOC,
  title={Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells.},
  author={Tomohiro Iida and Hiroshi Ohno and Chiaki Nakaseko and Machie Sakuma and Mitsue Takeda-Ezaki and Hisashi Arase and Eiki Kominami and Takao Fujisawa and Takashi K. Saito},
  journal={Journal of immunology},
  year={2000},
  volume={165 9},
  pages={5062-8}
}
CTLA-4 is expressed on the surface of activated T cells and negatively regulates T cell activation. Because a low-level expression of CTLA-4 on the cell surface is sufficient to induce negative signals in T cells, the surface expression of CTLA-4 is strictly regulated. We previously demonstrated that the association of CTLA-4 with the clathrin-associated adaptor complex AP-2 induces internalization of CTLA-4 and keeps the surface expression low. However, the mechanism to induce high expression… CONTINUE READING

From This Paper

Topics from this paper.
28 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…