Regulation of cell death by the ubiquitin-proteasome system.

  title={Regulation of cell death by the ubiquitin-proteasome system.},
  author={Maya Bader and Hermann Steller},
  journal={Current opinion in cell biology},
  volume={21 6},
The regulation of apoptosis (programmed cell death) has been the subject of a vast body of research because of its implications in normal development, tissue homeostasis and a wide range of diseases. The ubiquitin-proteasome system (UPS) plays a prominent role in the control of apoptosis by targeting key cell death proteins, including caspases, the central… CONTINUE READING