Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases.

  title={Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases.},
  author={Shun'ichi Kuroda and Masaki Fukata and Koichi Fujii and Toshikazu Nakamura and Ichiro Izawa and Kozo Kaibuchi},
  journal={Biochemical and biophysical research communications},
  volume={240 2},
Rac1, a member of the Rho small GTPases family, has recently been shown to be involved in the regulation of cell-cell adhesion mediated by cadherin. Here we showed that Cdc42, another member of Rho family, accumulated at cell-cell contact sites. Microinjection of Rho GDI, a negative regulator of the Rho family members, into Madin-Darby canine kidney (MDCK) cells resulted in perturbation of epithelial cell morphology and of cell-cell and cell-substratum adhesions, and comicroinjection of… CONTINUE READING

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