Regulation of cathepsin B activity by cysteine and related thiols.

@article{Kepela1999RegulationOC,
  title={Regulation of cathepsin B activity by cysteine and related thiols.},
  author={Ev{\vz}en Křepela and Jan Proch{\'a}zka and B K{\'a}rov{\'a}},
  journal={Biological chemistry},
  year={1999},
  volume={380 5},
  pages={
          541-51
        }
}
We studied the mode of regulation of the activity of mature cathepsin B (CB) by L-cysteine and some related thiols. The activity of CB with Z-Arg-Arg-NHMec as substrate was gradually inhibited over a range of increasing concentration of Cys, Cys methyl ester (CysOMe), Cys ethyl ester (CysOEt), N-acetyl-Cys (N-AcCys) and 3-mercaptopropionic acid. However, the inhibition of CB peaked at a definite value of [Cys], [CysOMe], [CysOEt] and [N-AcCys] and was gradually reversed over a range of higher… CONTINUE READING

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