Regulation of catch muscle by twitchin phosphorylation: effects on force, ATPase, and shortening.

@article{Butler1998RegulationOC,
  title={Regulation of catch muscle by twitchin phosphorylation: effects on force, ATPase, and shortening.},
  author={Thomas M. Butler and Susan U. Mooers and Chenqing Li and Srinivasa R Narayan and Marion J. Siegman},
  journal={Biophysical journal},
  year={1998},
  volume={75 4},
  pages={1904-14}
}
Recent experiments on permeabilized anterior byssus retractor muscle (ABRM) of Mytilus edulis have shown that phosphorylation of twitchin releases catch force at pCa > 8 and decreases force at suprabasal but submaximum [Ca2+]. Twitchin phosphorylation decreases force with no detectable change in ATPase activity, and thus increases the energy cost of force maintenance at subsaturating [Ca2+]. Similarly, twitchin phosphorylation causes no change in unloaded shortening velocity (Vo) at any [Ca2… CONTINUE READING