Regulation of casein kinase I epsilon activity by Wnt signaling.

  title={Regulation of casein kinase I epsilon activity by Wnt signaling.},
  author={Wojciech I Swiatek and I-Chun Tsai and Laura Klimowski and Andrea Pepler and Janet E Barnette and H Joseph Yost and David M Virshup},
  journal={The Journal of biological chemistry},
  volume={279 13},
The Wnt/beta-catenin signaling pathway is important in both development and cancer. Casein kinase Iepsilon (CKIepsilon) is a positive regulator of the canonical Wnt pathway. CKIepsilon itself can be regulated in vitro by inhibitory autophosphorylation, and recent data suggest that in vivo kinase activity can be regulated by extracellular stimuli. We show here that the phosphorylation state and kinase activity of CKIepsilon are directly regulated by Wnt signaling. Coexpression of XWnt-8 or… CONTINUE READING

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