Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling.

@article{Bobick2008RegulationOC,
  title={Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling.},
  author={Brent E. Bobick and William M. Kulyk},
  journal={Birth defects research. Part C, Embryo today : reviews},
  year={2008},
  volume={84 2},
  pages={131-54}
}
The majority of bones comprising the adult vertebrate skeleton are generated from hyaline cartilage templates that form during embryonic development. A process known as endochondral ossification is responsible for the conversion of these transient cartilage anlagen into mature, calcified bone. Endochondral ossification is a highly regulated, multistep cell specification program involving the initial differentiation of prechondrogenic mesenchymal cells into hyaline chondrocytes, terminal… CONTINUE READING

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