Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation.

@article{Hao2006RegulationOC,
  title={Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation.},
  author={Jianming Hao and Christina Michalek and Wei Zhang and Ming Zhu and Xiaomei Xu and Ulrike Mende},
  journal={Journal of molecular and cellular cardiology},
  year={2006},
  volume={41 1},
  pages={51-61}
}
Many signals that regulate cardiomyocyte growth, differentiation and function are mediated via heterotrimeric G proteins, which are under the control of RGS proteins (Regulators of G protein Signaling). Several RGS proteins are expressed in the heart, but so far little is known about their function and regulation. Using adenoviral gene transfer, we conducted the first comprehensive analysis of the capacity and selectivity of the major cardiac RGS proteins (RGS2-RGS5) to regulate central G… CONTINUE READING

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