Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

@article{Chien1991RegulationOC,
  title={Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response},
  author={Kenneth R Chien and Kirk U. Knowlton and Gao Zhu and Shu Chien},
  journal={The FASEB Journal},
  year={1991},
  volume={5},
  pages={3037 - 3046}
}
Studies from both in vivo and in vitro model systems have provided an initial skeleton of the potential signaling pathways that might regulate cardiac genes during growth and hypertrophy. One of the first detectable changes in cardiac gene expression is the activation of a program of immediate early gene expression, which is distinct for the hypertrophic response, and is conserved in multiple models of both in vivo and in vitro hypertrophy. Diverse and distinct hormonal stimuli have been… 
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