Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response
@article{Chien1991RegulationOC, title={Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response}, author={K. Chien and K. Knowlton and G. Zhu and S. Chien}, journal={The FASEB Journal}, year={1991}, volume={5}, pages={3037 - 3046} }
Studies from both in vivo and in vitro model systems have provided an initial skeleton of the potential signaling pathways that might regulate cardiac genes during growth and hypertrophy. One of the first detectable changes in cardiac gene expression is the activation of a program of immediate early gene expression, which is distinct for the hypertrophic response, and is conserved in multiple models of both in vivo and in vitro hypertrophy. Diverse and distinct hormonal stimuli have been… Expand
Topics from this paper
778 Citations
Signaling mechanisms for the activation of an embryonic gene program during the hypertrophy of cardiac ventricular muscle.
- Biology, Medicine
- Basic research in cardiology
- 1992
- 20
Expression of nuclear-acting early-response genes in the rat heart : implications for cardiac hypertrophy
- Biology
- 1994
- PDF
The role of protein kinases in adaptational growth of the heart.
- Biology, Medicine
- The international journal of biochemistry & cell biology
- 1996
- 73
Gene expression profiling reveals complex changes following MEK-EE expression in cardiac myocytes.
- Biology, Medicine
- The international journal of biochemistry & cell biology
- 2007
- 3
Early and transient gene expression changes in pressure overload-induced cardiac hypertrophy in mice.
- Biology, Medicine
- Genomics
- 2006
- 54
- PDF
Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction.
- Biology, Medicine
- The American journal of pathology
- 2001
- 98
Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy.
- Biology, Medicine
- Physiological genomics
- 2001
- 120
Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy
- Biology, Medicine
- The Journal of cell biology
- 1994
- 201
- PDF
References
SHOWING 1-10 OF 72 REFERENCES
Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1988
- 864
- PDF
Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes.
- Biology, Medicine
- The Journal of clinical investigation
- 1990
- 364
- PDF
Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells.
- Biology, Medicine
- Journal of molecular and cellular cardiology
- 1990
- 128
A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1988
- 425
- PDF
Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1986
- 249
- PDF
Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells.
- Biology, Medicine
- The Journal of clinical investigation
- 1989
- 117
Stretching cardiac myocytes stimulates protooncogene expression.
- Biology, Medicine
- The Journal of biological chemistry
- 1990
- 476
Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.
- Biology, Medicine
- The Journal of clinical investigation
- 1987
- 442
- PDF