Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.

@article{Leenders2010RegulationOC,
  title={Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.},
  author={Joost J G Leenders and Wino J. Wijnen and Monika Hiller and Ingeborg van der Made and Viola Lentink and Rick E.W. van Leeuwen and Veronica H{\'e}rias and Saraswati Pokharel and Stephane Heymans and Leon De Windt and Morten Andre H\oydal and Yigal M. Pinto and Esther E J M Creemers},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 35},
  pages={27449-56}
}
Pathological forms of left ventricular hypertrophy (LVH) often progress to heart failure. Specific transcription factors have been identified that activate the gene program to induce pathological forms of LVH. It is likely that apart from activating transcriptional inducers of LVH, constitutive transcriptional repressors need to be removed during the development of cardiac hypertrophy. Here, we report that the constitutive presence of Krüppel-like factor 15 (KLF15) is lost in pathological… CONTINUE READING
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Regulation of Cardiac Gene Expression by KLF15 27456 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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