Regulation of cardiac calcium current by NO and cGMP-modulating agents

@article{Gallo2001RegulationOC,
  title={Regulation of cardiac calcium current by NO and cGMP-modulating agents},
  author={M. Gallo and D. Malan and I. Bedendi and C. Biasin and G. Alloatti and R. Levi},
  journal={Pfl{\"u}gers Archiv},
  year={2001},
  volume={441},
  pages={621-628}
}
  • M. Gallo, D. Malan, +3 authors R. Levi
  • Published 2001
  • Chemistry, Medicine
  • Pflügers Archiv
  • Abstract. Several effects of nitric oxide (NO) on the control of L-type calcium current (ICa) and of calcium handling in cardiomyocytes have been described. Cardiomyocytes have been shown to express in different conditions all types of nitric oxide synthases (NOS), but the role of NO in the regulation of calcium current remains controversial. Previously, we have shown in guinea pig ventricular cells a stimulatory effect of NOS inhibitors on ICa. Here we investigate the intracellular mechanisms… CONTINUE READING
    46 Citations
    The Role of Nitric Oxide in the Regulation of Mechanically Gated Channels in the Heart
    • Victor Kazanski, Andre Kamkin, +4 authors Irina Kiseleva
    • Chemistry
    • 2010
    • 8
    Cyclic AMP and cyclic GMP independent stimulation of ventricular calcium current by peroxynitrite donors in guinea pig myocytes
    • 34
    Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component?
    • C. Sears, E. Ashley, B. Casadei
    • Biology, Medicine
    • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
    • 2004
    • 87
    Nitric-oxide-mediated regulation of cardiac contractility and stretch responses.
    • 85
    Influence of NO and [Ca2+]o on [Ca2+]i homeostasis in rat ventricular cardiomyocytes
    • 2

    References

    SHOWING 1-10 OF 31 REFERENCES
    A cellular mechanism for nitric oxide-mediated cholinergic control of mammalian heart rate
    • 155
    • PDF
    Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.
    • 671
    • PDF
    Modulation of guinea‐pig cardiac L‐type calcium current by nitric oxide synthase inhibitors
    • 65
    An obligatory role for nitric oxide in autonomic control of mammalian heart rate.
    • 222
    Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase.
    • X. Han, I. Kubota, +7 authors R. Kelly
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1998
    • 160
    • PDF