Regulation of cardiac calcium current by NO and cGMP-modulating agents

@article{Gallo2001RegulationOC,
  title={Regulation of cardiac calcium current by NO and cGMP-modulating agents},
  author={Maria Pia Gallo and Daniela Malan and Ivano Bedendi and Cinzia Biasin and Giuseppe Alloatti and Renzo Cesare Levi},
  journal={Pfl{\"u}gers Archiv},
  year={2001},
  volume={441},
  pages={621-628}
}
Several effects of nitric oxide (NO) on the control of L-type calcium current (I Ca) and of calcium handling in cardiomyocytes have been described. Cardiomyocytes have been shown to express in different conditions all types of nitric oxide synthases (NOS), but the role of NO in the regulation of calcium current remains controversial. Previously, we have shown in guinea pig ventricular cells a stimulatory effect of NOS inhibitors on I Ca. Here we investigate the intracellular mechanisms involved… CONTINUE READING

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