Regulation of cardiac calcium current by NO and cGMP-modulating agents

  title={Regulation of cardiac calcium current by NO and cGMP-modulating agents},
  author={M. Gallo and D. Malan and I. Bedendi and C. Biasin and G. Alloatti and R. Levi},
  journal={Pfl{\"u}gers Archiv},
  • M. Gallo, D. Malan, +3 authors R. Levi
  • Published 2001
  • Chemistry, Medicine
  • Pflügers Archiv
  • Abstract. Several effects of nitric oxide (NO) on the control of L-type calcium current (ICa) and of calcium handling in cardiomyocytes have been described. Cardiomyocytes have been shown to express in different conditions all types of nitric oxide synthases (NOS), but the role of NO in the regulation of calcium current remains controversial. Previously, we have shown in guinea pig ventricular cells a stimulatory effect of NOS inhibitors on ICa. Here we investigate the intracellular mechanisms… CONTINUE READING
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