Regulation of cardiac beta-adrenergic receptors by captopril. Implications for congestive heart failure.

@article{Maisel1989RegulationOC,
  title={Regulation of cardiac beta-adrenergic receptors by captopril. Implications for congestive heart failure.},
  author={Alan S. Maisel and Chris Phillips and Martin C Michel and Michael G. Ziegler and Steven M. Carter},
  journal={Circulation},
  year={1989},
  volume={80 3},
  pages={669-75}
}
The interaction of the renin-angiotensin system and the sympathetic nervous system in patients with congestive heart failure is not well understood. We tested the hypothesis that angiotensin-converting enzyme inhibitors can resensitize the beta-adrenergic receptor system. Guinea pigs were given captopril, isoproterenol, or both for 2 weeks. At death, cardiac sarcolemmal and light vesicle fractions and intact mononuclear leukocytes were prepared. Captopril treatment led to an up-regulation of… CONTINUE READING