Regulation of capsule in Neisseria meningitidis.

  title={Regulation of capsule in Neisseria meningitidis.},
  author={Yih-ling Tzeng and Jennifer Lee Thomas and David S. Stephens},
  journal={Critical reviews in microbiology},
  volume={42 5},
Neisseria meningitidis, a devastating pathogen exclusive to humans, expresses capsular polysaccharides that are the major meningococcal virulence determinants and the basis for successful meningococcal vaccines. With rare exceptions, the expression of capsule (serogroups A, B, C, W, X, Y) is required for systemic invasive meningococcal disease. Changes in capsule expression or structure (e.g. hypo- or hyper-encapsulation, capsule "switching", acetylation) can influence immunologic diagnostic… CONTINUE READING