Regulation of cancer metabolism by oncogenes and tumor suppressors.

@article{Iurlaro2014RegulationOC,
  title={Regulation of cancer metabolism by oncogenes and tumor suppressors.},
  author={Raffaella Iurlaro and Clara Luc{\'i}a Le{\'o}n-Annicchiarico and Cristina Mu{\~n}oz-Pinedo},
  journal={Methods in enzymology},
  year={2014},
  volume={542},
  pages={59-80}
}
Cell proliferation requires the coordination of multiple signaling pathways as well as the provision of metabolic substrates. Nutrients are required to generate such building blocks and their form of utilization differs to significant extents between malignant tissues and their nontransformed counterparts. Thus, oncogenes and tumor suppressor genes regulate the proliferation of cancer cells also by controlling their metabolism. Here, we discuss the central anabolic functions of the signaling… CONTINUE READING
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