Regulation of calcium release by interdomain interaction within ryanodine receptors.

@article{Ikemoto2002RegulationOC,
  title={Regulation of calcium release by interdomain interaction within ryanodine receptors.},
  author={Noriaki Ikemoto and Takeshi Yamamoto},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2002},
  volume={7},
  pages={d671-83}
}
In excitation-contraction (E-C) coupling, various types of activation signals, which are received presumably at the bulky cytoplasmic domain of the ryanodine receptor (RyR), are translated (or transduced) into the opening of the Ca2+ release channel located in the trans-membrane domain of the RyR. In order to elucidate the detailed mechanism of the signal transduction process, it is essential (i) to identify various sub-domains of the RyR that are involved in the Ca2+ channel regulation, (ii… CONTINUE READING

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