Regulation of calcium release by interdomain interaction within ryanodine receptors.

  title={Regulation of calcium release by interdomain interaction within ryanodine receptors.},
  author={Noriaki Ikemoto and Takeshi Yamamoto},
  journal={Frontiers in bioscience : a journal and virtual library},
In excitation-contraction (E-C) coupling, various types of activation signals, which are received presumably at the bulky cytoplasmic domain of the ryanodine receptor (RyR), are translated (or transduced) into the opening of the Ca2+ release channel located in the trans-membrane domain of the RyR. In order to elucidate the detailed mechanism of the signal transduction process, it is essential (i) to identify various sub-domains of the RyR that are involved in the Ca2+ channel regulation, (ii… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 69 extracted citations

Ligand-dependent conformational changes in the clamp region of the cardiac ryanodine receptor.

The Journal of biological chemistry • 2013
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 107 references

Ikemoto : Spectroscopic monitoring of local conformational changes during the intramolecular domaindomain interaction of the ryanodine receptor

T. Yamamoto, N.
Biochemistry • 2002

Danieli : Mutations in the Cardiac Ryanodine Receptor Gene ( hRyR 2 ) Underlie Catecholaminergic Polymorphic Ventricular Tachycardia

S. G. Priori, A. G.
Hum Mol Genet • 2001

Excitation - contraction coupling is unaffected by drastic alteration of the sequence surrounding residues L 720L 764 of the alpha 1 S IIIII loop

C. M. Wilkens, B. E. Flucher, K. G. Beam, M. Grabner
Proc Natl Acad Sci USA • 2001

FKBP 12 binds the inositol 1 , 4 , 5trisphosphate receptor at leucineproline ( 14001401 ) and anchors calcineurin to this FK 506like domain

A. M. Cameron, F. C. Nucifora, +4 authors S. H. Snyder
J Biol Chem • 2001

Hamilton : Calcium binding to calmodulin leads to an N - terminal shift in its binding site on the ryanodine Receptor

L. S.
J Biol Chem • 2001

Similar Papers

Loading similar papers…