Regulation of calcium release by calcium inside the sarcoplasmic reticulum in ventricular myocytes

@article{Lukyanenko1996RegulationOC,
  title={Regulation of calcium release by calcium inside the sarcoplasmic reticulum in ventricular myocytes},
  author={Valeriy Lukyanenko and Inna Gy{\"o}rke and S{\'a}ndor Gy{\"o}rke},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={1996},
  volume={432},
  pages={1047-1054}
}
To study the effects of changes in sarcoplasmic reticulum (SR) intraluminal Ca2+ on the Ca2+ release mechanism, we correlated the activity of single cardiac ryanodine receptor (RyR) channels, monitored in planar bilayers, with the properties of spontaneous elementary Ca2+ release events (sparks) in intact ventricular myocytes, monitored by scanning confocal microfluorimetry. Under both normal conditions and Ca2+ overload, induced by elevation of extracellular [Ca2+], Ca2+ sparks represented… CONTINUE READING
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