Regulation of calcium phosphate formation by amelogenins under physiological conditions.

@article{Kwak2011RegulationOC,
  title={Regulation of calcium phosphate formation by amelogenins under physiological conditions.},
  author={S Y Kwak and Samantha E Green and Felicitas B. Wiedemann-Bidlack and Elia Beniash and Yasuo Yamakoshi and James P. Simmer and Henry C. Margolis},
  journal={European journal of oral sciences},
  year={2011},
  volume={119 Suppl 1},
  pages={103-11}
}
Amelogenin is essential for proper enamel formation. The present in vitro study extends our previous work at low (10 mM) ionic strength (IS) by examining the effect of amelogenin on mineralization under higher (162 mM) IS conditions found in developing enamel. Full-length phosphorylated (P173) and non-phosphorylated (rP172) amelogenins were examined, along with P148 and rP147 that lack the hydrophilic C-terminus. Calcium phosphate formation was assessed by pH change, while the minerals formed… CONTINUE READING