Regulation of calcium in pancreatic α- and β-cells in health and disease

  title={Regulation of calcium in pancreatic α- and β-cells in health and disease},
  author={Patrik Rorsman and Mathias Braun and Quan Zhang},
  booktitle={Cell calcium},
The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we discuss the mechanisms that underlie the reciprocal regulation of insulin and glucagon secretion by changes in plasma glucose, the roles played by different types of voltage-gated Ca… CONTINUE READING
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