Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells.

  title={Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells.},
  author={Sergei D. Rybalkin and Irina G Rybalkina and Robert Feil and Franz Hofmann and Joseph A. Beavo},
  journal={The Journal of biological chemistry},
  volume={277 5},
Nitric oxide and endogenous nitrovasodilators regulate smooth muscle tone by elevation of cGMP and activation of cyclic GMP-dependent protein kinase (PKG). The amplitude and duration of the cGMP signal in smooth muscle is regulated in large part by cGMP-specific cyclic nucleotide phosphodiesterase (PDE5). Previous in vitro data have suggested that both cAMP-dependent protein kinase and PKG can regulate the activity of PDE5. To test if this type of regulation is important in the intact cell, we… CONTINUE READING
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