Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.

@article{Ramana2000RegulationOC,
  title={Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.},
  author={Chilakamarti V. Ramana and Nicolas Grammatikakis and Mikhail Chernov and Hannah N Nguyen and Kee Chuan Goh and Bret R. Williams and George R Stark},
  journal={The EMBO journal},
  year={2000},
  volume={19 2},
  pages={263-72}
}
Interferons (IFNs) inhibit cell growth in a Stat1-dependent fashion that involves regulation of c-myc expression. IFN-gamma suppresses c-myc in wild-type mouse embryo fibroblasts, but not in Stat1-null cells, where IFNs induce c-myc mRNA rapidly and transiently, thus revealing a novel signaling pathway. Both tyrosine and serine phosphorylation of Stat1 are required for suppression. Induced expression of c-myc is likely to contribute to the proliferation of Stat1-null cells in response to IFNs… CONTINUE READING