Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons

@article{Kumar2015RegulationOB,
  title={Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons},
  author={Natasha N. Kumar and Ana Velic and Jorge Soliz and Yingtang Shi and Keyong Li and Sheng Wang and Janelle L Weaver and Josh Sen and Stephen B G Abbott and Roman M Lazarenko and Marie-Gabrielle Ludwig and Edward Perez-Reyes and Nilufar Mohebbi and Carla Bettoni and Max Gassmann and Thomas Suply and Klaus Seuwen and Patrice G Guyenet and Carsten A Wagner and Douglas A Bayliss},
  journal={Science},
  year={2015},
  volume={348},
  pages={1255-1260}
}
Blood gas and tissue pH regulation depend on the ability of the brain to sense CO2 and/or H+ and alter breathing appropriately, a homeostatic process called central respiratory chemosensitivity. We show that selective expression of the proton-activated receptor GPR4 in chemosensory neurons of the mouse retrotrapezoid nucleus (RTN) is required for CO2-stimulated breathing. Genetic deletion of GPR4 disrupted acidosis-dependent activation of RTN neurons, increased apnea frequency, and blunted… CONTINUE READING
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