Regulation of brain aromatase activity in rats.

  title={Regulation of brain aromatase activity in rats.},
  author={C E Roselli and W E Ellinwood and John A. Resko},
  volume={114 1},
We studied the distribution and regulation of aromatase activity in the adult rat brain with a sensitive in vitro assay that measures the amount of 3H2O formed during the conversion of [1 beta-3H]androstenedione to estrone. The rate of aromatase activity in the hypothalamus-preoptic area (HPOA) was linear with time up to 1 h, and with tissue concentrations up to 5 mgeq/200 microliters incubation mixture. The enzyme demonstrated a pH optimum of 7.4 and an apparent Michaelis-Menten constant (Km… CONTINUE READING


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