Regulation of bradykinin-induced cyclic AMP response by quinacrine and prostaglandin E2 and F2α in human synovial fibroblasts

@article{Fahey1979RegulationOB,
  title={Regulation of bradykinin-induced cyclic AMP response by quinacrine and prostaglandin E2 and F2α in human synovial fibroblasts},
  author={John V. Fahey and David S. Newcombe},
  journal={Inflammation},
  year={1979},
  volume={3},
  pages={235-242}
}
Bradykinin induces an increment in intracellular cyclic AMP concentrations of human synovial fibroblasts and evokes the release of [3H] arachidonic acid and [3H]-E prostaglandins from human synovial fibroblasts prelabeled in their phospholipids. Both these bradykinin-induced reactions are inhibited by quinacrine, an inhibitor of phospholipase A activity. The cyclic AMP response of human synovial fibroblasts to bradykinin is potentiated by prostaglandin E2 and inhibited by prostaglandin F2… CONTINUE READING