Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.

@article{Southwood2008RegulationOB,
  title={Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.},
  author={Mark R. Southwood and Trina K. Jeffery and Xinping Yang and Paul D Upton and Susan E. M. Hall and Charles S. Atkinson and Sheila. G. Haworth and Susan Gessner Stewart and Paul N Reynolds and Liangyuan Long and Richard C Trembath and Nicholas W Morrell},
  journal={The Journal of pathology},
  year={2008},
  volume={214 1},
  pages={
          85-95
        }
}
The bone morphogenetic protein (BMP) type II receptor (BMPR-II) is predominantly expressed on the vascular endothelium in the adult lung. Although mutations in BMPR-II are known to underlie many cases of familial pulmonary arterial hypertension (FPAH), little is known regarding the expression of BMPs and their signalling pathways during normal lung development or the impact of BMPR-II mutations on endothelial cell function. We determined the cellular localization and expression levels of BMP4… CONTINUE READING
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