Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure.

@article{Csiszr2005RegulationOB,
  title={Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure.},
  author={Anna Csisz{\'a}r and Kira E Smith and A. E. Koller and Gabor Kaley and John G. Edwards and Zoltan Ungvari},
  journal={Circulation},
  year={2005},
  volume={111 18},
  pages={2364-72}
}
BACKGROUND Recent studies suggest that bone morphogenetic protein-2 (BMP-2), a transforming growth factor-beta superfamily member cytokine, plays an important role both in vascular development and pathophysiological processes, including endothelial activation that is likely to contribute to the development of coronary atherosclerosis, yet the factors that regulate arterial expression of BMP-2 are completely unknown. We tested the hypothesis that BMP-2 expression in endothelial cells is governed… CONTINUE READING