Regulation of bone metabolism by Wnt signals.

@article{Kobayashi2016RegulationOB,
  title={Regulation of bone metabolism by Wnt signals.},
  author={Yasuhiro Kobayashi and Shunsuke Uehara and Nobuyuki Udagawa and Naoyuki Takahashi},
  journal={Journal of biochemistry},
  year={2016},
  volume={159 4},
  pages={387-92}
}
Wnt ligands play a central role in the development and homeostasis of various organs through β-catenin-dependent and -independent signalling. The crucial roles of Wnt/β-catenin signals in bone mass have been established by a large number of studies since the discovery of a causal link between mutations in the low-density lipoprotein receptor-related protein 5 (Lrp5) gene and alternations in human bone mass. The activation of Wnt/β-catenin signalling induces the expression of osterix, a… CONTINUE READING

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Furthermore , this signalling induces the expression of osteoprotegerin , an osteoclast inhibitory factor in osteoblast - lineage cells to prevent bone resorption .
Furthermore , this signalling induces the expression of osteoprotegerin , an osteoclast inhibitory factor in osteoblast - lineage cells to prevent bone resorption .
Furthermore , this signalling induces the expression of osteoprotegerin , an osteoclast inhibitory factor in osteoblast - lineage cells to prevent bone resorption .
Furthermore , this signalling induces the expression of osteoprotegerin , an osteoclast inhibitory factor in osteoblast - lineage cells to prevent bone resorption .
OsteoblastsSibling in is aOsteoclasts
Furthermore , this signalling induces the expression of osteoprotegerin , an osteoclast inhibitory factor in osteoblast - lineage cells to prevent bone resorption .
OsteoclastsSibling in is aOsteoblasts
Furthermore , this signalling induces the expression of osteoprotegerin , an osteoclast inhibitory factor in osteoblast - lineage cells to prevent bone resorption .
Furthermore , this signalling induces the expression of osteoprotegerin , an osteoclast inhibitory factor in osteoblast - lineage cells to prevent bone resorption .
Furthermore , this signalling induces the expression of osteoprotegerin , an osteoclast inhibitory factor in osteoblast - lineage cells to prevent bone resorption .
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