Regulation of bone formation and remodeling by G-protein-coupled receptor 48.

  title={Regulation of bone formation and remodeling by G-protein-coupled receptor 48.},
  author={Jian Luo and Wei Zhou and Xin Zhou and Dali Li and Jinsheng Weng and Zhengfang Yi and Sung Gook Cho and Chenghai Li and Tingfang Yi and Xiushan Wu and Xiaoying Li and Benoit de Crombrugghe and Magnus H{\"o}{\"o}k and Mingyao Liu},
  volume={136 16},
G-protein-coupled receptor (GPCR) 48 (Gpr48; Lgr4), a newly discovered member of the glycoprotein hormone receptor subfamily of GPCRs, is an orphan GPCR of unknown function. Using a knockout mouse model, we have characterized the essential roles of Gpr48 in bone formation and remodeling. Deletion of Gpr48 in mice results in a dramatic delay in osteoblast differentiation and mineralization, but not in chondrocyte proliferation and maturation, during embryonic bone formation. Postnatal bone… CONTINUE READING
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