Regulation of body weight and energy homeostasis by neuronal Cell adhesion molecule 1

@inproceedings{Rathjen2017RegulationOB,
  title={Regulation of body weight and energy homeostasis by neuronal Cell adhesion molecule 1},
  author={Thomas Rathjen and Xin Yan and Natalia L Kononenko and Min-Chi Ku and Kun Song and Leiron Ferrarese and Valentina Tarallo and Dmytro Puchkov and Gaga Kochlamazashvili and Sebastian Brachs and L P{\'e}rez Varela and Klara Szigeti-Buck and Chun-xia Yi and Sonja C Schriever and Sudhir Gopal Tattikota and Anne Sophie Carlo and Mirko Moroni and Jan Siemens and Arnd Heuser and Louise van der Weyden and Andreas L Birkenfeld and Thoralf Niendorf and James F. A. Poulet and Tam{\'a}s L. Horv{\'a}th and Matthias H Tsch{\"o}p and Matthias Heinig and Mirko Trajkovski and Volker Haucke and Matthew N Poy},
  booktitle={Nature Neuroscience},
  year={2017}
}
Susceptibility to obesity is linked to genes regulating neurotransmission, pancreatic beta-cell function and energy homeostasis. Genome-wide association studies have identified associations between body mass index and two loci near cell adhesion molecule 1 (CADM1) and cell adhesion molecule 2 (CADM2), which encode membrane proteins that mediate synaptic assembly. We found that these respective risk variants associate with increased CADM1 and CADM2 expression in the hypothalamus of human… CONTINUE READING