Regulation of blood-testis barrier dynamics: an in vivo study.

  title={Regulation of blood-testis barrier dynamics: an in vivo study.},
  author={Ching-hang Wong and Dolores D. Mruk and Wing-yee Lui and C. Yan Cheng},
  journal={Journal of cell science},
  volume={117 Pt 5},
An in vivo model was used to investigate the regulation of tight junction (TJ) dynamics in the testis when adult rats were treated with CdCl(2). It was shown that the CdCl(2)-induced disruption of the blood-testis barrier (BTB) associated with a transient induction in testicular TGF-beta2 and TGF-beta3 (but not TGF-beta1) and the phosphorylated p38 mitogen activated protein (MAP) kinase, concomitant with a loss of occludin and zonula occludens-1 (ZO-1) from the BTB site in the seminiferous… CONTINUE READING