Regulation of blood pressure by the type 1A angiotensin II receptor gene.

@article{Ito1995RegulationOB,
  title={Regulation of blood pressure by the type 1A angiotensin II receptor gene.},
  author={Mitsuhiro Ito and Michael I. Oliverio and Peter Joseph Mannon and Christopher F. Best and Nobuyo N Maeda and Oliver Smithies and Thomas M. Coffman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 8},
  pages={
          3521-5
        }
}
The renin-angiotensin system plays a critical role in sodium and fluid homeostasis. Genetic or acquired alterations in the expression of components of this system are strongly implicated in the pathogenesis of hypertension. To specifically examine the physiological and genetic functions of the type 1A receptor for angiotensin II, we have disrupted the mouse gene encoding this receptor in embryonic stem cells by gene targeting. Agtr1A(-/-) mice were born in expected numbers, and the… CONTINUE READING

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