Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels.

Abstract

The blood-brain tumor barrier (BTB) limits the delivery of therapeutic drugs to brain tumors. We demonstrate in a rat brain tumor (RG2) model an enhanced drug delivery to brain tumor following intracarotid infusion of bradykinin (BK), nitric oxide (NO) donors, or agonists of soluble guanylate cyclase (sGC) and calcium-dependent potassium (K(Ca)) channels… (More)

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Cite this paper

@article{Ningaraj2002RegulationOB, title={Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels.}, author={Nagendra S. Ningaraj and M. Keshava Rao and Kazuhiro Hashizume and Kamlesh Asotra and Keith L. Black}, journal={The Journal of pharmacology and experimental therapeutics}, year={2002}, volume={301 3}, pages={838-51} }