Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha.

  title={Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha.},
  author={H{\'e}l{\`e}ne Duez and Jelske N. van der Veen and Christian Duhem and Beno{\^i}t Pourcet and Thierry Touvier and Coralie Fontaine and Bruno Derudas and Eric Baug{\'e} and Rick Havinga and Vincent W. Bloks and H. -J. Wolters and Fjodor H van der Sluijs and Bj{\"o}rn Vennstr{\"o}m and Folkert Kuipers and Bart Staels},
  volume={135 2},
BACKGROUND & AIMS Conversion into bile acids represents an important route to remove excess cholesterol from the body. Rev-erbalpha is a nuclear receptor that participates as one of the clock genes in the control of circadian rhythmicity and plays a regulatory role in lipid metabolism and adipogenesis. Here, we investigate a potential role for Rev-erbalpha in the control of bile acid metabolism via the regulation of the neutral bile acid synthesis pathway. METHODS Bile acid synthesis and… CONTINUE READING


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