Regulation of beta-cell mass by hormones and growth factors.

  title={Regulation of beta-cell mass by hormones and growth factors.},
  author={Jens H Nielsen and Elisabeth Douglas Galsgaard and Annette M\oldrup and Birgitte Nissen Friedrichsen and Nils Billestrup and Johnny Arnsdorf Hansen and Ying Chu Lee and Carina Carlsson},
  volume={50 Suppl 1},
Substantial new information has accumulated on molecular mechanisms of pancreas development, regulation of beta-cell gene expression, and the role of growth factors in the differentiation, growth, and regeneration of beta-cells. The present review focuses on some recent studies on the mechanism of action of cytokines such as growth hormone (GH) and prolactin (PRL) in beta-cell proliferation and gene expression-in particular, the role of signal transducers and activators of transcription (STAT… CONTINUE READING


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