Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

  title={Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol},
  author={Hao Wang and Joshua A Kulas and Chao Wang and David M. Holtzman and Heather A. Ferris and Scott B. Hansen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  • Hao Wang, Joshua A Kulas, +3 authors Scott B. Hansen
  • Published 2021
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Significance The accumulation of amyloid β (Aβ) in the brain appears to be a necessary event in the pathogenesis of Alzheimer’s disease (AD). However, processes linked to the endogenous regulation of Aβ production are still not completely understood. Here, the authors show that Aβ accumulation in neurons is tightly regulated by cholesterol synthesis and apoE transport from astrocytes. The study provides a molecular context for understanding the endogenous regulation of Aβ accumulation and why… Expand

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