Regulation of bacterial drug export systems.

  title={Regulation of bacterial drug export systems.},
  author={Steve Grkovic and Melissa H Brown and Ronald A. Skurray},
  journal={Microbiology and molecular biology reviews : MMBR},
  volume={66 4},
  pages={671-701, table of contents}
The active transport of toxic compounds by membrane-bound efflux proteins is becoming an increasingly frequent mechanism by which cells exhibit resistance to therapeutic drugs. This review examines the regulation of bacterial drug efflux systems, which occurs primarily at the level of transcription. Investigations into these regulatory networks have yielded a substantial volume of information that has either not been forthcoming from or complements that obtained by analysis of the transport… CONTINUE READING
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