Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.

  title={Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.},
  author={Jonathan P Myers and Miguel Santiago-Medina and Timothy M Gomez},
  journal={Developmental neurobiology},
  volume={71 11},
Developing neurons use a combination of guidance cues to assemble a functional neural network. A variety of proteins immobilized within the extracellular matrix (ECM) provide specific binding sites for integrin receptors on neurons. Integrin receptors on growth cones associate with a number of cytosolic adaptor and signaling proteins that regulate cytoskeletal dynamics and cell adhesion. Recent evidence suggests that soluble growth factors and classic axon guidance cues may direct axon… CONTINUE READING
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