Regulation of axon growth in vivo by activity-based competition

  title={Regulation of axon growth in vivo by activity-based competition},
  author={Jackie Yuanyuan Hua and Matthew C Smear and H. Baier and S. Smith},
  • Jackie Yuanyuan Hua, Matthew C Smear, +1 author S. Smith
  • Published 2005
  • Biology, Medicine
  • Nature
  • The formation of functional neural networks requires precise regulation of the growth and branching of the terminal arbors of axons, processes known to be influenced by early network electrical activity. Here we show that a rule of activity-based competition between neighbouring axons appears to govern the growth and branching of retinal ganglion cell (RGC) axon arbors in the developing optic tectum of zebrafish. Mosaic expression of an exogenous potassium channel or a dominant-negative SNARE… CONTINUE READING
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