Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer.

@article{Hughes2006RegulationOA,
  title={Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer.},
  author={Thomas A. Hughes and Hugh J M Brady},
  journal={Cancer letters},
  year={2006},
  volume={233 2},
  pages={338-47}
}
Axin2 is a negative regulator of Wnt/beta-catenin signalling with a role in tumour suppression. Its expression can be up-regulated by E2F1 allowing cross-talk between the pRb/E2F and Wnt/beta-catenin pathways, which both have critical roles in the development of many cancers. Thereby, axin2 may have a crucial role in carcinogenesis and here we examine the regulation of its expression. Axin2 mRNAs contain one of three different 5' untranslated regions that can have profound effects on the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Immunohistochemical study of the canonical and non-canonical Wnt signaling pathway in colorectal carcinoma and non-neoplastic mucosa

Rodrigo Felippe Ramosa, Thiago Simão Gomesb, Ana Maria Amaral Antonio Maderc, Caio Dal Moro Alvesd, Jaques Waisbergd
2015

Alternative RNA Structure-Coupled Gene Regulations in Tumorigenesis

International journal of molecular sciences • 2014
View 1 Excerpt

Expression of β-catenin and AXIN2 in ameloblastomas

Contemporary oncology • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…