Regulation of autophagy through multiple independent hypoxic signaling pathways.

  title={Regulation of autophagy through multiple independent hypoxic signaling pathways.},
  author={Kasper M A Rouschop and Bradly G. Wouters},
  journal={Current molecular medicine},
  volume={9 4},
The poorly developed vasculature in solid human tumors is responsible for a profound level of intra- and inter-tumor heterogeneity in oxygen concentration. High levels of hypoxia are associated with poor patient prognosis due in part to hypoxia-induced changes in cell metabolism, angiogenesis, invasiveness and resistance to therapy. Over the past decade several distinct oxygen sensing pathways that regulate the cellular response to hypoxia have been defined. These include transcriptional and… CONTINUE READING


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