Regulation of autophagy by the inositol trisphosphate receptor

@article{Criollo2007RegulationOA,
  title={Regulation of autophagy by the inositol trisphosphate receptor},
  author={Alfredo Criollo and Maria Chiara Maiuri and Ezgi Tasdemir and Ilio Vitale and Aline Fiebig and Darrell Andrews and Jordi Molg{\'o} and Jose Diaz and Sergio Lavandero and Francis Harper and G{\'e}rard Pierron and Domenica Di Stefano and Rosario Rizzuto and Gyorgy Szabadkai and Guido Kroemer},
  journal={Cell Death and Differentiation},
  year={2007},
  volume={14},
  pages={1029-1039}
}
The reduction of intracellular 1,4,5-inositol trisphosphate (IP3) levels stimulates autophagy, whereas the enhancement of IP3 levels inhibits autophagy induced by nutrient depletion. Here, we show that knockdown of the IP3 receptor (IP3R) with small interfering RNAs and pharmacological IP3R blockade is a strong stimulus for the induction of autophagy. The IP3R is known to reside in the membranes of the endoplasmic reticulum (ER) as well as within ER–mitochondrial contact sites, and IP3R… CONTINUE READING

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References

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SHOWING 1-10 OF 35 REFERENCES

Inhibition of macroautophagy triggers apoptosis.

VIEW 5 EXCERPTS

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

Autophagy in cell death: an innocent convict?

VIEW 1 EXCERPT

Autophagy in metazoans: cell survival in the land of plenty

VIEW 1 EXCERPT

Autophagy: molecular machinery for self-eating

VIEW 1 EXCERPT