Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells.

@article{Zhu2009RegulationOA,
  title={Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells.},
  author={Hua Zhu and Hao Wu and Xiuping Liu and Biao Li and Yun Chen and Xingcong Ren and Chang-gong Liu and Jin-ming Yang},
  journal={Autophagy},
  year={2009},
  volume={5 6},
  pages={816-23}
}
beclin 1, the mammalian homologue of the yeast Atg6, is a key autophagy-promoting gene that plays a critical role in the regulation of cell death and survival of various types of cells. However, recent studies have observed that the expression of beclin 1 is altered in certain diseases including cancers. The causes underlying the aberrant expression of beclin 1 remain largely unknown. We report here that microRNAs (miRNAs), a class of endogenous, 22-24 nucleotide noncoding RNA molecules able to… CONTINUE READING
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